Impact Report

Research Outcome: Grant 1731: ‘I feel it in my gut’ – an unexpected relationship between gut bacteria and brain disease in dogs

Researchers identified strong evidence that Meningoencephalomyelitis of unknown origin (MUO) might be triggered by specific imbalances in the bacteria in the gut. The identification of changes in gut bacteria as a specific risk is important because it suggests that it might be possible to change the risk of developing disease, or treat affected dogs, by changing the population of bacteria in the gut.

Research Outcome: Grant 02128-A: Redefining the Recommendations for Prevention of Infectious Disease at Dog Shows and Other Areas Where Dogs Meet and Compete

To help dog owners and event organizers better understand and prevent transmission of infectious diseases in dogs, the AKC Canine Health Foundation, in collaboration with the Orthopedic Foundation for Animals, funded a study in order to provide practical guidelines to reduce the risk of disease spread in the canine population. Principal Investigator, Dr. Jason Stull, VMD, PhD, Ohio State University, provides details about the impact of this important research study.

Research Outcome: Grant 2133: Canine Epilepsy: Genetic Variants, Biomarkers, and New Therapies

Researchers have tested and demonstrated the safe use of an intravenous drug to treat seizure emergencies in dogs with epilepsy. These findings may also prove important for human epilepsy.

Research Outcome: Grant  02148-A: The Prevalence of the Dal-Negative Blood Type and Its Mode of Inheritance in Doberman Pinschers and in Dalmatians

Researchers identified the prevalence of the Dal antigen expression in dogs, and the mode of inheritance of the Dal+ phenotype.

Research Outcome:  Grant 02248: Identification of a Novel Juvenile Myoclonic Epilepsy Gene and Its Underlying Disease Mechanism

Researchers have identified a new gene linked to juvenile epilepsy in dogs. Finding this gene defect has important implications for understanding epilepsy, and could help treat epilepsy in both dogs and humans.

Research Spotlight: Degenerative Myelopathy

Degenerative myelopathy (DM) is a devastating neurodegenerative disease that affects multiple breeds of dog. Your investment looks at therapeutic approaches that may improve survival and preserve neurologic function in DM-affected dogs. 

Research Spotlight: Hemangiosarcoma

Hemangiosarcoma is an aggressive form of cancer in dogs. Your investment is funding a research study that looks at the ways in which hemangiosarcoma may rely on lipid metabolism for proliferation and growth. Findings from this study will be used to inhibit the interactions between tumor cells and the tumor environment, ultimately leading to improved outcomes from this disease.

Research Spotlight: Lyme Disease

Lyme disease impacts both pets and people. Your investment is funding a research study that tracks dogs that test positive for Lyme disease. These findings aim to improve prevention and control methods, benefiting both dogs and humans.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

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