NEW RESEARCH INSIGHTS INTO CANINE ADDISON'S DISEASE

Addison’s disease is an autoimmune endocrine disorder in which the body attacks and destroys the outer layer of the adrenal gland, called the adrenal cortex. Dogs with Addison’s disease are at high risk of developing a potentially deadly adrenal crisis characterized by shock, vomiting, and life-threatening electrolyte abnormalities. Treatment for Addison’s disease is manageable but requires frequent monitoring and lifelong hormone supplementation. The disease is believed to be inherited in several dog breeds including Standard Poodles, Portuguese Water Dogs, and Cocker Spaniels.

In this presentation Dr. Friedenberg will discuss the latest research into the causes of Addison’s disease. He will also share specific insights into the underlying genetics and immunology of the disease. Finally, recent publications, ongoing studies, and the latest research into what might trigger the onset of this challenging autoimmune disease will be highlighted.

Original Air Date: November 20, 2019

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Learn more about Dr. Friedenberg's CHF-funded research:
Grant 02428: Identifying the Disease-Defining Autoantibodies in Canine Addison's Disease
Grant 02348: Whole Blood Transcriptome Profiling of Dogs with Immune-Mediated Hemolytic Anemia (IMHA)
Grant 02531 (Co-investigator): Identification of Genetic Risk Allele(s) Associated with the Development of Tricuspid Valve Dysplasia in the Labrador Retriever