Genetic Test for Canine Hyperuricosuria

05/17/2010

Introduction

Hyperuricosuria means elevated levels of uric acid in the urine. This trait predisposes dogs to form stones in their bladders or sometimes kidneys. These stones often must be removed surgically and can be difficult to treat. Hyperuricosuria is inherited as a simple autosomal recessive trait. The trait can occur in any breed but is most commonly found in the Dalmatian, Bulldog and Black Russian Terrier.  Dalmatians are considered to be homozygous for hyperuricosuria. A mutation in exon 5 of the gene Solute carrier family 2, member 9 (SLC2A9) has been found to be associated with hyperuricosuria in dogs.  A DNA test for this specific mutation can determine if dogs are normal or if they carry one or two copies of the mutation. Dogs that carry two copies of the mutation will be affected and susceptible to develop bladder/kidney stones.

ORDER TEST KITS - Allow 5-10 business days for test results.

Detailed Hyperuricosuria Information

The VGL offers a DNA test for hyperuricosuria to assist owners and breeders in identifying affected and carrier dogs. The test uses DNA collected from buccal swabs thus avoiding invasive blood collection. Breeders can use results from the test as a tool for selection of mating pairs to avoid producing affected dogs. The test is offered to all breeds, including Dalmatian, Bulldog, Black Russian Terrier, Weimaraner, Jack Russell/Parsons Terrier, Pitbull, American Staffordshire Terrier, Giant Schnauzer, South African Boerboel, German Shepherd, Large Munsterlander, and Australian Shepherd.

The following chart details the expected outcomes of matings for all possible combinations of hyperuricosuria genotypes.

 

 

Female

 

 

Male 

 

 

N/N

N/HU

HU/HU

N/N

100% N/N

50% N/N, 50% N/HU

100% N/HU

N/HU

50% N/N, 50% N/HU

25% N/N, 50% N/HU, 25% HU/HU

50% N/HU, 50% HU/HU

HU/HU

100% N/HU

50% N/HU, 50% HU/HU

100% HU/HU

 

Research Hyperuricosuria is ongoing to determine other breeds with this problem.  We recommend testing any dog that has formed kidney or bladder stones composed of urate or uric acid. If the dog has the mutation then treatment modalities for Dalmatians can be used to treat the dog.

The DNA test offered by VGL is based on research in Dr. Danika Bannasch’s laboratory at the School of Veterinary Medicine, UC Davis, recently published in the journal PLoS Genetics 2008 Nov 7th. Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog. Danika Bannasch, Noa Safra, Amy Young, Nili Karmi, R. S. Schaible, G. V. Ling.

For more information, contact the UC Davis Veterinary Genetics Laboratory at 530-752-2211 or via their website, www.vgl.ucdavis.edu/services/dog.php.

 

 

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